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Sunday 20 May 2012

Sulfisoxazole

Class: Sulfonamide

Mech.: Comp. inhib. of PABA incorp. into dihydropteric acid → inhib. of folic acid.
Bacteriostatic.

Absorption: Rapidly absorbed in GI tract. Parenteral.
Distribution: Widely distrib; CSF. Crosses placenta.
Metab.: Acetylated in liver
Excretion, t_: Renal filtration, secretion

Toxicity/S.E.s: Hypersensitivity—fever, rash, photosensitivity; UT disturbances- deposition of crystalline aggregates; hematopoetic disorders-dyscrasias

Utility: Uncomplicated UTIs, trachoma (contag. disease of eyelid, conjunct, cornea), nocardiosis (tuberculosis-like infect.), prophylaxis (burnt skin, suppressing recurring UTIs, rheumatic fever)
Special Features: Spectrum—gram +, gram -. Less renal toxicity than other sulfas. Protoype.

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