Mech.: Acts on two sequential steps in synth of folic acid. PABA competitive
inhib, dihydrofolate reductase inhib. Bacteriostatic.
Absorption: Oral, IV
Distribution:
Metab.:
Excretion, t_:
Toxicity/S.E.s: Megaloblastic anemia, leukopenia, granulocytopenia (prevented by admin. of folic acid)
Utility: Uncomp. UTIs, otitis media, acute exacerbations of chronic bronchitis, various pneumonias. DOC for Travelers’ diarrhea, P. carinii pneumonia, Shigella enteritis, systemic Salmonella infects, prostatitis.
Special Features: Trimethoprim = highly selective inhib. of bacterial dihydrofolate reductase.
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